FB2025_01 , released February 20, 2025
Allele: Dmel\SclAUAS.cMa
Open Close
General Information
Symbol
Dmel\SclAUAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Magny
FlyBase ID
FBal0288568
Feature type
allele
Associated gene
Dmel\SclA
Associated Insertion(s)
Carried in Construct
M{UAS-SclA.M}
Key Links
Transgenic product class
wild_type
(Magny et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Magny et al., 2013)
Mutagen
in vitro construct
(Magny et al., 2013)
Progenitor genotype
Carried in construct
M{UAS-SclA.M}
Cytology
Description

UAS regulatory sequences drive expression of the SclA coding sequence (plus 86bp downstream and 16bp upstream sequence).

(Magny et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
SclA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing SclAScer\UAS.cMa under the control of Scer\GAL4Mef2.PR show significantly more cardiac arrhythmicity compared to control flies.

      (Magny et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      SclAUAS.cMa/Scer\GAL4Mef2.PR rescues Df(2L)Scl12/Df(2L)Sclg6

      (Magny et al., 2013)
      Comments

      Expression of SclAScer\UAS.cMa under the control of Scer\GAL4Mef2.PR rescues the increased cardiac arrhythmicity seen in Df(2L)Scl12/Df(2L)Sclg6 adults.

      (Magny et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SclAScer\UAS.cMa
      SclAUAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Magny
      Secondary FlyBase IDs
        References (2)