FB2025_01 , released February 20, 2025
Allele: Dmel\tkoB
Open Close
General Information
Symbol
Dmel\tkoB
Species
D. melanogaster
Name
FlyBase ID
FBal0291341
Feature type
allele
Associated gene
Dmel\tko
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Graves et al., 2020, Yamamoto et al., 2013-)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q6term.

(Graves et al., 2020, Yamamoto et al., 2013-)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,443,770..2,443,770 [-]
Nucleotide change:

C2443770T

Amino acid change:

Q6term | tko-PB

Reported amino acid change:

Q6term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Haelterman et al., 2014, Yamamoto et al., 2013-)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tkoB clones in mosaic early third instar larval fat bodies do not show defects in cell size compared to controls; these cells do not accumulate autophagosome-like structures (Atg8a-positive), as compared to controls.

      (Liu et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      tko3

      (Yamamoto et al., 2013-)
      Comments

      Rescued by: Dp(1;3)DC452.

      (Yamamoto et al., 2013-)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      XE30B
      (Graves et al., 2020)
      XGCB043
      (Graves et al., 2020)
      tkoB
      (Graves et al., 2020, Yamamoto et al., 2013-)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)