FB2025_01 , released February 20, 2025
Allele: Dmel\HpdMI12465
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General Information
Symbol
Dmel\HpdMI12465
Species
D. melanogaster
Name
FlyBase ID
FBal0299502
Feature type
allele
Associated gene
Dmel\Hpd
Associated Insertion(s)
Mi{MIC}HpdMI12465
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{MIC}HpdMI12465
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{MIC}
    Also carries
    attP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  Alzheimer's disease
        modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
        (Belfiori-Carrasco et al., 2017)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        HpdMI12465 heterozygosity has no significant effect in the adult locomotor capacity (in negative geotaxis assays) in 18 days old adults and has no obvious effect on the adult brain, as compared to controls.

        (Belfiori-Carrasco et al., 2017)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        NOT Enhancer of
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        HpdMI12465 heterozygosity enhances the adult locomotion defects, but has no effect on the adult brain loss and vacuolization, induced by the expression of Hsap\APPAβ42.UAS.Tag:SS(rPENK) under the control of Scer\GAL4elav-C155.

        (Belfiori-Carrasco et al., 2017)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CG11796MI12465
        (Bellen, 2014.11.3)
        CG11796Mut
        (Belfiori-Carrasco et al., 2017)
        HpdMI12465
        Name Synonyms
        Secondary FlyBase IDs
          References (2)