FB2025_01 , released February 20, 2025
Allele: Dmel\Mul1LD.UAS
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General Information
Symbol
Dmel\Mul1LD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0301078
Feature type
allele
Associated gene
Dmel\Mul1
Associated Insertion(s)
Carried in Construct
P{UAS-Mul1.LD}
Key Links
Transgenic product class
missense_variant
(Yun et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yun et al., 2014)
Mutagen
in vitro construct
(Yun et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Mul1.LD}
Cytology
Description

UASt regulatory sequences drive expression of a ligase-dead form of Mul1 (contains the amino acid replacement H307A).

(Yun et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mul1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4Mef2.PU/Mul1LD.UAS is a non-suppressor of increased cell death phenotype of Pink15

      (Yun et al., 2014)

      Scer\GAL4Mef2.PU/Mul1LD.UAS is a non-suppressor of visible phenotype of Pink15

      (Yun et al., 2014)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4Mef2.PU/Mul1LD.UAS is a non-suppressor of indirect flight muscle cell phenotype of Pink15

      (Yun et al., 2014)

      Scer\GAL4Mef2.PU/Mul1LD.UAS is a non-suppressor of adult thorax | dorsal phenotype of Pink15

      (Yun et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Mul1LD.Scer\UAS under the control of Scer\GAL4Mef2.PU does not suppress the abnormal clumping of mitochondria or muscle cell death seen in the indirect flight muscles of Pink15 adults. The thoracic indentation seen in Pink15 adults is also not suppressed.

      (Yun et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mul1LD.Scer\UAS
      Mul1LD.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)