FB2025_01 , released February 20, 2025
Allele: Dmel\Mul1A6
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General Information
Symbol
Dmel\Mul1A6
Species
D. melanogaster
Name
FlyBase ID
FBal0301081
Feature type
allele
Associated gene
Dmel\Mul1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Yun et al., 2014)
Mutagen
P-element activity
(Yun et al., 2014)
Progenitor genotype
P{EPgy2}Mul1EY12156
(Yun et al., 2014)
Cytology
Description

Imprecise excision of the progenitor P{EPgy2}Mul1EY12156 insertion, resulting in a deletion that removes part of Mul1.

(Yun et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Doktór et al., 2019)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease 2
      modeled by park25
      (Zhang et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mul1A6/Mul1A6 adult flies have an increased duration of total activity but similar daytime and nighttime sleep compared to controls. Under constant dark conditions, flies display a longer period of locomotor activity rhythm.

      (Doktór et al., 2019)

      Homozygous flies have slightly elongated mitochondria in the indirect flight muscles compared to wild type.

      (Yun et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      Statement
      Reference

      Mul1A6 is an enhancer of adult thorax | dorsal phenotype of Pink15

      (Yun et al., 2014)

      Mul1A6 is an enhancer of adult thorax | dorsal phenotype of park25

      (Yun et al., 2014)
      Other
      Statement
      Reference

      Mul1A6, Pink15 has mitochondrion phenotype

      (Yun et al., 2014)

      Mul1A6, park25 has mitochondrion phenotype

      (Yun et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The degree of thoracic indentation seen in park25 Mul1A6 is much more severe than that seen in park25 single mutants. The thoracic indentation phenotype of park25 Mul1A6 double mutants is almost completely suppressed by expression of MarfmiRNA.cUa.Scer\UAS under the control of Scer\GAL4unspecified.

      The indirect flight muscles of park25 Mul1A6 mutants have highly elongated and interconnected mitochondria. This phenotype can be suppressed by expression of MarfmiRNA.cUa.Scer\UAS under the control of Scer\GAL4unspecified.

      The degree of thoracic indentation seen in Pink15 Mul1A6 is much more severe than that seen in Pink15 single mutants.

      The indirect flight muscles of Pink15 Mul1A6 mutants have highly elongated and interconnected mitochondria.

      (Yun et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      MUL1A6
      (Cheramangalam et al., 2023, Yun et al., 2014)
      Mul1A6
      (Sanchez-Martinez et al., 2023)
      mul1A6
      (Doktór et al., 2019, Zhang et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)