FB2025_01 , released February 20, 2025
Allele: Dmel\dor30
Open Close
General Information
Symbol
Dmel\dor30
Species
D. melanogaster
Name
FlyBase ID
FBal0301187
Feature type
allele
Associated gene
Dmel\dor
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Fernandes et al., 2014)
Progenitor genotype
Cytology
Description

Amino acid replacement: W551term.

(Fernandes et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:1,666,890..1,666,890 [+]
Nucleotide change:

G1666890A

Amino acid change:

W551term | dor-PA

Reported amino acid change:

W551term

Comment:

TGG to TAG mutation reported in Trp codon.

(Fernandes et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by sky2
      (Fernandes et al., 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Females in which the eye is homozygous show electroretinogram defects.

      (Fernandes et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      dor[+]/dor30 is a suppressor | partially of abnormal neurophysiology | somatic clone | adult stage phenotype of sky2

      (Fernandes et al., 2014)

      dor[+]/dor30 is a suppressor of abnormal neuroanatomy | somatic clone | progressive phenotype of sky2

      (Fernandes et al., 2014)

      dor[+]/dor30 is a suppressor of abnormal neurophysiology | third instar larval stage phenotype of sky1/sky2

      (Fernandes et al., 2014)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      dor[+]/dor30 is a suppressor of retina | somatic clone | progressive phenotype of sky2

      (Fernandes et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The electroretinogram defects seen in homozygous sky2 eyes are partially suppressed if the flies are also heterozygous for dor30.

      The progressive retina neurodegeneration seen in flies containing homozygous sky2 eyes is suppressed if the flies are also heterozygous for dor30.

      The increase in excitatory junctional current amplitude at the neuromuscular junction which is seen in sky1/sky2 larvae is suppressed if they are also heterozygous for dor30.

      (Fernandes et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dor30
      (Fernandes et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)