FB2025_01 , released February 20, 2025
Allele: Hsap\GOSR1ninaE.PR
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General Information
Symbol
Hsap\GOSR1ninaE.PR
Species
H. sapiens
Name
neither inactivation nor afterpotential E promoter construct of Rosenbaum
FlyBase ID
FBal0303957
Feature type
allele
Associated gene
Hsap\GOSR1
Associated Insertion(s)
Carried in Construct
P{ninaE-GOSR1.R}
Key Links
Transgenic product class
cDNA
(Rosenbaum et al., 2014)
wild_type
(Rosenbaum et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Rosenbaum et al., 2014)
wild_type
(Rosenbaum et al., 2014)
Mutagen
in vitro construct
(Rosenbaum et al., 2014)
Progenitor genotype
Carried in construct
P{ninaE-GOSR1.R}
Cytology
Description

The construct contains a full-length Hsap\GOSR1 cDNA under the control of ninaE promoter sequences.

(Rosenbaum et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
ninaE
Encoded product / tool
Hsap\GOSR1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by Gos281
      (Rosenbaum et al., 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Hsap\GOSR1ninaE.PR is a suppressor of retina phenotype of Gos281

      (Rosenbaum et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Introduction of Hsap\GOSR1ninaE.PR into the genome of the Gos281 mutant prevents retinal degeneration in Gos281 mutants.

      (Rosenbaum et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\GOSR1ninaE.PR
      Name Synonyms
      neither inactivation nor afterpotential E promoter construct of Rosenbaum
      Secondary FlyBase IDs
        References (1)