FB2025_01 , released February 20, 2025
Allele: Dmel\Neto203
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General Information
Symbol
Dmel\Neto203
Species
D. melanogaster
Name
FlyBase ID
FBal0314785
Feature type
allele
Associated gene
Dmel\Neto
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
minos activity
(Ramos et al., 2015)
Progenitor genotype
Mi{ET1}NetoMB07125
(Ramos et al., 2015)
Cytology
Description

Imprecise excision of Mi{ET1}NetoMB07125 has resulted in a deletion ( X:13 ,521,082..13,524,084 (R6)), including part of exon 13 and 14 of Neto.

(Ramos et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neto203 mutant adult flies have no apparent defects.

      The spontaneous miniature excitatory junctional potential (mEJP) amplitude and frequency are reduced in Neto203 mutant third instar larvae. Evoked EJP amplitude is slightly reduced. Quantal content is increased compared to controls.

      Neto203 mutant NMJS have fewer but larger type Ib boutons. The enlarged Neto203 mutant boutons have diminished or absent subsynaptic reticulum (SSR) structures.

      Neto203 mutant NMJs have an increased number of synaptic contacts, and their density is increased at proximal but not distal boutons.

      The active zones of Neto203 mutant NMJs often have abnormal T-bar structures. Postsynaptic density (PSD) length is significantly reduced compared to controls.

      (Ramos et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Neto203
      neto-βshort
      (Han et al., 2020)
      neto203
      (Ramos et al., 2015)
      netoβshort
      (Ramos et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)