FB2025_01 , released February 20, 2025
Allele: Dmel\RelVDRC.cUa
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General Information
Symbol
Dmel\RelVDRC.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0319751
Feature type
allele
Associated gene
Dmel\Rel
Associated Insertion(s)
Carried in Construct
P{VDRC.Rel.U}
Key Links
Transgenic product class
RNAi_reagent
(Cao et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Cao et al., 2013)
Mutagen
in vitro construct
(Cao et al., 2013)
Progenitor genotype
Carried in construct
P{VDRC.Rel.U}
Cytology
Description

UAS drives expression of a VDRC RNAi construct targeting Rel.

(Cao et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Rel
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of RelVDRC.cUa under the control of Scer\GAL4c564 blocks the normal inflammatory response to Gram-negative (assessed by the expression levels of Diptericin) bacterial infection, but has no effect under basal, non-infected conditions, as compared to controls.

      (Kumar et al., 2016)

      Bacterial injection in the head leads to neurodegeneration in fly brains (compared to control sterile injections) and locomotion defects at 25 days old; these phenotypes are suppressed by expression of RelVDRC.cUa driven by Scer\GAL4repo.PU or Scer\GAL4elav.PU.

      (Cao et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of RelVDRC.cUa does not suppress age-dependent neurodegeneration in fly brains with DefScer\UAS.cUa or DrsScer\UAS.cUa driven by Scer\GAL4repo.PU.

      (Cao et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      RelVDRC.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)