FB2025_01 , released February 20, 2025
Allele: Dmel\MenUAS.cKa
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General Information
Symbol
Dmel\MenUAS.cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0324940
Feature type
allele
Associated gene
Dmel\Men
Associated Insertion(s)
Carried in Construct
P{UAS-Men}
Key Links
Transgenic product class
cDNA
(Kim et al., 2015)
wild_type
(Kim et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Kim et al., 2015)
wild_type
(Kim et al., 2015)
Mutagen
in vitro construct
(Kim et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-Men}
Cytology
Description

UAS regulatory sequences drive expression of the Men open reading frame (derived from the LD27718 cDNA clone).

(Kim et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Men
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing MenScer\UAS.cKa under the control of Scer\GAL4Switch1.106 during larval stages only, by feeding RU486, leads to both male and female adults having increased lifespan compared to controls; feeding RU486 to adults did not significantly affect their lifespan, as compared to controls.

      Expressing MenScer\UAS.cKa under the control of Scer\GAL4Switch1.106 during larval stages (by feeding RU486) results in similar eclosion rate, developmental time and fecundity as controls; expressing MenScer\UAS.cKa under the control of Scer\GAL4Switch1.106 during larval stages (by feeding RU486) also results in increased survival to paraquat-induced oxidative stress but not significantly to acute starvation or heat stress, as compared to controls.

      Larvae expressing MenScer\UAS.cKa under the control of Scer\GAL4Switch1.106 and fed RU486 have decreased body weight (despite no change in food ingestion) and a range of metabolic defects.

      (Kim et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MenScer\UAS.cKa
      MenUAS.cKa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)