FB2025_01 , released February 20, 2025
Allele: Dmel\pgcΔ
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General Information
Symbol
Dmel\pgcΔ
Species
D. melanogaster
Name
FlyBase ID
FBal0337969
Feature type
allele
Associated gene
Dmel\pgc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Flora et al., 2018)
Progenitor genotype
P{EPgy2}pgcEY07794
(Flora et al., 2018)
Cytology
Description

475bp deletion that completely deletes the pgc open reading frame.

(Flora et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pgcΔ homozygous females are less fecund (i.e. lay significantly less eggs) than controls. Their germaria show an abnormal accumulation of undifferentiated, pre-cystoblast cells, often away from the stem cell niche, but without significant changes on the rate of germline stem cell division, as compared to controls.

      pgcΔ homozygous clones are less frequent than control clones at 3 to 10 days after clone induction.

      (Flora et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The abnormal accumulation of undifferentiated, pre-cystoblast cells observed in pgcΔ homozygous germaria is partially suppressed by the expression of CycBScer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

      (Flora et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      pgcΔ is rescued by pgcTag:FLAG

      (Flora et al., 2018)
      Comments

      The accumulation of undifferentiated pre-cystoblast cells observed in pgcΔ homozygous germaria is rescued by pgcT:Zzzz\FLAG.

      (Flora et al., 2018)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      pgcΔ
      (Flora et al., 2018, Flora et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)