FB2025_01 , released February 20, 2025
Allele: Dmel\vib1105
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General Information
Symbol
Dmel\vib1105
Species
D. melanogaster
Name
FlyBase ID
FBal0341707
Feature type
allele
Associated gene
Dmel\vib
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Koe et al., 2018)
Mutagen
ethyl methanesulfonate
(Koe et al., 2018)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Most vib1105 homozygous somatic clones in the larval brain show variable numbers of type I and type II neuroblasts (absent or ectopic), as compared to control clones.

      vib1105/vibj5A6 transheterozygous larval brain neuroblasts frequently display defective asymmetric cell divisions, as compared to controls: aPKC, Par6, and Gαi, but not Baz, Insc, Pins and Cdc42, fail to localize to a strong apical cortex crescent during metaphase; Mira, Pros, Brat, Numb and Pon fail to localize to a strong basal cortex crescent during metaphase; and the mitotic spindle axis is misoriented with respect to the neuroblast polarity.

      (Koe et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      vib1105 is partially rescued by vibUAS.Venus/Scer\GAL4elav.PLu

      (Koe et al., 2018)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      vib1105
      (Koe et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)