FB2025_01 , released February 20, 2025
Allele: Dmel\InosΔDF
Open Close
General Information
Symbol
Dmel\InosΔDF
Species
D. melanogaster
Name
FlyBase ID
FBal0342220
Feature type
allele
Associated gene
Dmel\Inos
Associated Insertion(s)
P+PBac{XP3.WH3}InosΔDF
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Jackson et al., 2018)
Mutagen
FLPase
(Jackson et al., 2018)
Progenitor genotype
PBac{WH}f00895
(Jackson et al., 2018)
P{XP}Inosd00881
(Jackson et al., 2018)
Associated Insertion(s)
P+PBac{XP3.WH3}InosΔDF
Cytology
Description

Deletion extending from 40bp upstream of the Inos gene to 670bp downstream of it. Generated by FLP-mediated recombination between the FRT sites present in the PBac{WH}f00895 and P{XP}d00881 progenitor insertions.

(Jackson et al., 2018)
Allele components
Component
Use(s)
Inserted element
P+PBac{XP3.WH3}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:7,454,252..7,458,914 [-]
Comment:

Deletion extending from 40bp upstream of the Inos gene to 670bp downstream of it. Generated by Scer\FLP1-mediated recombination between the FRT sites present in the PBac{WH}f00895 and P{XP}d00881 progenitor insertions.

(Jackson et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  azoospermia
      CEA
      (Jackson et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      InosΔDF individuals reared in inositol-containing diets show normal hatching rates and normal life-span, as compared to controls.

      InosΔDF males show exhibit normal mating behavior including copulation but their testes are smaller and more fragile than controls and no waste bag is observed, the seminal vesicle lacks mature sperm, the spermatid bundles are irregularly-shaped. In agreement, wild-type females mated to InosΔDF males have virgin-like ovaries and seminal receptacles and eggs do not appear to be fertilized.

      (Jackson et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      InosΔDF is partially rescued by Inos+tCH322-61O14

      (Jackson et al., 2018)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      InosΔDF
      inosΔDF
      (Jackson et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)