UASt regulates expression of a recombinant virokine Diedel (SfAV-1a\die) in which the putative signal peptide from the viral protein is replaced with the Drosophila signal peptide sequence.
Expressing DiedelUAS.cMa under the control of Scer\GAL4Act88F.1.3 leads to a significantly lower increase in mitosis in the adult midgut during aging or in response to Ecc15 bacterial infection, as compared to controls.
Scer\GAL4Cg.PA-driven expression blocks the Ecc15 bacterial infection-induced increase in mitosis in the adult midgut normally observed in controls.