FB2025_01 , released February 20, 2025
Allele: Dmel\Slc25A46aRNAi.UAS.217-383
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General Information
Symbol
Dmel\Slc25A46aRNAi.UAS.217-383
Species
D. melanogaster
Name
FlyBase ID
FBal0359509
Feature type
allele
Associated gene
Dmel\Slc25A46a
Associated Insertion(s)
Carried in Construct
P{UAS-Slc25A46a.RNAi.217-383}
Key Links
Transgenic product class
RNAi_reagent
(Ali et al., 2020)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ali et al., 2020)
Mutagen
in vitro construct
(Ali et al., 2020)
Progenitor genotype
Carried in construct
P{UAS-Slc25A46a.RNAi.217-383}
Cytology
Description

UAS regulates expression of a tandem repeat of a region corresponding to aa residues 217 to 383 at the C-terminal region of Slc25A46a, with the second repeat in reverse orientation to the first to create a dsRNA hairpin.

(Ali et al., 2020)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Slc25A46a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Charcot-Marie-Tooth disease type 6
      CEA
      (Ali et al., 2020)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Individuals expressing Slc25A46adsRNA.UAS.217-383 under the control of Scer\GAL4elav.PLu show a progressive decrease in adult climbing ability. Larvae show decreased crawling ability. The third instar larval neuromuscular junction shows smaller branches, fewer type 1b boutons and larger mitochondria, as compared to controls.

      (Ali et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Slc25A46aRNAi.UAS.217-383
      Slc25A46adsRNA.UAS.217-383
      Name Synonyms
      Secondary FlyBase IDs
        References (2)