FB2025_01 , released February 20, 2025
Allele: Dmel\aPKCHC
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General Information
Symbol
Dmel\aPKCHC
Species
D. melanogaster
Name
FlyBase ID
FBal0360441
Feature type
allele
Associated gene
Dmel\aPKC
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Chen et al., 2018)
Mutagen
CRISPR/Cas9
(Chen et al., 2018)
Progenitor genotype
Cytology
Description

Small deletion results in a missense frameshift mutation, leading to a premature stop codon and truncation of aPKC at amino acid 409.

(Chen et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
complex_substitution
2R:14,948,115..14,948,126 [-]
Comment:

A base substitution followed by a two base deletion leads to a missense mutation and then a frameshift at codon 401 of aPKC-RA. This results in early translation termination after the addition of nine novel amino acids.

Inserted_sequence:

TTCACGAGGG

(Chen et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      aPKCHC/aPKC[+] is a suppressor | partially of egg chamber phenotype of RhoGAP19Dunspecified

      (Fic et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      aPKCHC
      (Fic et al., 2021, Chen et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)