FlyBase Allele Report: Dmel\Ras64B[3]

General Information

Symbol

Dmel\Ras64B³

Species

D. melanogaster

Name

FlyBase ID

FBal0360570

Feature type

allele

Associated gene

Dmel\Ras64B

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Vega-Cuesta et al., 2020)

Progenitor genotype

Cytology

Description

Frameshift mutation within Ras64B; results in a premature stop codon.

(Vega-Cuesta et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:4,139,937..4,139,941 [+]

Comment:

Deletion of 5bp leads to a frameshift and early translation termination. Nucleotide change in mutant inferred from reported amino acid change.

(Vega-Cuesta et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Vega-Cuesta et al., 2020)

fertile

(Vega-Cuesta et al., 2020)

hypoplasia | adult stage

(Vega-Cuesta et al., 2020)

long lived

(Vega-Cuesta et al., 2020)

viable

(Vega-Cuesta et al., 2020)

Phenotype Manifest In

wing

(Vega-Cuesta et al., 2020)

wing cell | decreased number

(Vega-Cuesta et al., 2020)

Detailed Description

Statement

Reference

Ras64B³ homozygotes exhibit smaller wings.

(Vega-Cuesta et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Ras64B³/Ras64B³ is an enhancer of decreased size | adult stage phenotype of Ras85D^GD12553, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Ras64B³/Ras64B³ is an enhancer of visible | adult stage phenotype of Ras85D^GD12553, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Ras64B³/Ras64B³ is an enhancer of decreased cell size | adult stage phenotype of Ras85D^GD12553, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Phenotype Manifest In

Enhancer of

Statement

Reference

Ras64B³/Ras64B³ is an enhancer of wing phenotype of Ras85D^GD12553, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Ras64B³/Ras64B³ is an enhancer of wing cell phenotype of Ras85D^GD12553, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ras2³

(Vega-Cuesta et al., 2020)

Ras64B³

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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