FlyBase Allele Report: Dmel\Drp1[SD.UASp]

General Information

Symbol

Dmel\Drp1^SD.UASp

Species

D. melanogaster

Name

FlyBase ID

FBal0373244

Feature type

allele

Associated gene

Dmel\Drp1

Associated Insertion(s)

Carried in Construct

P{UASp-Drp1.SD}

Key Links

Transgenic product class

dominant_negative_variant

(Dubal et al., 2022)

missense_variant

(Dubal et al., 2022)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

dominant_negative_variant

(Dubal et al., 2022)

missense_variant

(Dubal et al., 2022)

Mutagen

in vitro construct

(Dubal et al., 2022)

Progenitor genotype

Carried in construct

P{UASp-Drp1.SD}

Cytology

Description

UASp regulatory sequences drive expression of mutant Drp1 in which the conserved residue in the GTPase domain (Ser 193) is mutated to aspartic acid.

(Dubal et al., 2022)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Drp1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

intermediate neuronal progenitor | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

larval brain | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

mitochondrion | larval stage, with Scer\GAL4^Mhc.PW

(Dubal et al., 2022)

mitochondrion | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage, with Scer\GAL4^Mhc.PW

(Dubal et al., 2022)

muscle cell of A1-7 ventral longitudinal muscle 4 | larval stage, with Scer\GAL4^Mhc.PW

(Dubal et al., 2022)

type II neuroblast | larval stage, with Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Detailed Description

Statement

Reference

The expression of Drp1^SD.UASp under the control of Scer\GAL4^pnt-14-94 results in type II neuroblasts and daughter mature intermediate precursor cells in the larval brain with clustered mitochondria.

The expression of Drp1^SD.UASp under the control of Scer\GAL4^Mhc.PW results in larval muscles with enlarged mitochondria.

(Dubal et al., 2022)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of decreased cell number | larval stage phenotype of N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of decreased cell number | larval stage phenotype of Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of increased occurrence of cell division | larval stage phenotype of Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of decreased occurrence of cell division | larval stage phenotype of Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^wor.PU is a suppressor | partially of increased occurrence of cell division | larval stage phenotype of Marf^RNAi.UTR.UAS, Scer\GAL4^wor.PU

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor of abnormal neuroanatomy | larval stage phenotype of Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of decreased cell number | larval stage phenotype of Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor of decreased occurrence of cell division | larval stage phenotype of Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^wor.PU is a suppressor of decreased occurrence of cell division | larval stage phenotype of Opa1^HMS00349, Scer\GAL4^wor.PU

(Dubal et al., 2022)

Other

Statement

Reference

Drp1^SD.UASp, Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94 has increased occurrence of cell division | larval stage phenotype

(Dubal et al., 2022)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 has mitochondrion | larval stage phenotype, non-suppressible by Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 has larval brain phenotype, non-suppressible by Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 has type II neuroblast | larval stage phenotype, non-suppressible by Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 has intermediate neuronal progenitor | larval stage phenotype, non-suppressible by Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 has larval brain phenotype, non-suppressible by Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 has type II neuroblast | larval stage phenotype, non-suppressible by Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 has intermediate neuronal progenitor | larval stage phenotype, non-suppressible by Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 has mitochondrion | larval stage phenotype, non-suppressible by Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Suppressor of

Statement

Reference

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of larval brain | larval stage phenotype of N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of intermediate neuronal progenitor | larval stage | decreased number phenotype of N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of larval brain phenotype of Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of larval neuron | larval stage | decreased number phenotype of Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of intermediate neuronal progenitor | larval stage phenotype of Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of ganglion mother cell | larval stage phenotype of Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^wor.PU is a suppressor | partially of larval brain | larval stage phenotype of Marf^RNAi.UTR.UAS, Scer\GAL4^wor.PU

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^wor.PU is a suppressor | partially of type II neuroblast | larval stage phenotype of Marf^RNAi.UTR.UAS, Scer\GAL4^wor.PU

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of larval brain phenotype of Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor of intermediate neuronal progenitor | larval stage | decreased number phenotype of Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor of ganglion mother cell | larval stage | decreased number phenotype of Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor | partially of larval neuron | larval stage | decreased number phenotype of Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a suppressor of intermediate neuronal progenitor | larval stage phenotype of Opa1^HMS00349, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^wor.PU is a suppressor of type II neuroblast | larval stage phenotype of Opa1^HMS00349, Scer\GAL4^wor.PU

(Dubal et al., 2022)

NOT Suppressor of

Statement

Reference

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a non-suppressor of ganglion mother cell | larval stage | decreased number phenotype of N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a non-suppressor of type II neuroblast | larval stage | decreased number phenotype of N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Drp1^SD.UASp, Scer\GAL4^pnt-14-94 is a non-suppressor of larval neuron | larval stage | decreased number phenotype of N^{5XUAS.JF01356}, Scer\GAL4^pnt-14-94

(Dubal et al., 2022)

Other

Statement

Reference

Drp1^SD.UASp, Marf^RNAi.UTR.UAS, Scer\GAL4^pnt-14-94 has type II neuroblast | larval stage phenotype

(Dubal et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of Drp1^SD.UASp and Marf^{miRNA.UTR.UAS} under the control of Scer\GAL4^pnt-14-94 results in type II neuroblasts in the larval brain showing decreased mitotic index.

(Dubal et al., 2022)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Drp1^SD.UASp

Drp1^SD

(Dubal et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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General Information
Nature of the Allele
Expression Data
Human Disease Associations
Phenotypic Data
Interactions
Complementation and Rescue Data
Images
Stocks
Notes On Origin
Crossreferences
Synonyms and Secondary IDs
References