FlyBase Allele Report: Dmel\scramb1[43]

General Information

Symbol

Dmel\scramb1⁴³

Species

D. melanogaster

Name

FlyBase ID

FBal0403884

Feature type

allele

Associated gene

Dmel\scramb1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Castillo-Mancho et al., 2024)

Mutagen

P-element activity

(Castillo-Mancho et al., 2024)

Progenitor genotype

P{EPgy2}scramb1^EY07744

(Castillo-Mancho et al., 2024)

Cytology

Description

Imprecise excision of P{EPgy2}scramb1^EY07744 results in a 2.9kb deletion including transcription start sites of scramb1.

(Castillo-Mancho et al., 2024)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:10,223,219..10,226,083 [-]

Comment:

A 2865bp deletion in scramb1, which includes the transcription start.

(Culi and Ruiz-Gómez, 2024.8.9)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Castillo-Mancho et al., 2024)

viable

(Castillo-Mancho et al., 2024)

Phenotype Manifest In

embryonic/larval garland cell | larval stage

(Castillo-Mancho et al., 2024)

nephrocyte (with scramb1^{MI01181-GFSTF.0})

(Castillo-Mancho et al., 2024)

slit diaphragm (with scramb1^{MI01181-GFSTF.0})

(Castillo-Mancho et al., 2024)

slit diaphragm | absent | larval stage

(Castillo-Mancho et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

scramb1⁴³ has embryonic/larval garland cell | larval stage phenotype, non-enhanceable by scramb2^V6

(Castillo-Mancho et al., 2024)

scramb1⁴³ has slit diaphragm | larval stage | absent phenotype, non-enhanceable by scramb2^V6

(Castillo-Mancho et al., 2024)

NOT suppressed by

Statement

Reference

scramb1⁴³ has embryonic/larval garland cell | larval stage phenotype, non-suppressible by scramb2^V6

(Castillo-Mancho et al., 2024)

scramb1⁴³ has slit diaphragm | larval stage | absent phenotype, non-suppressible by scramb2^V6

(Castillo-Mancho et al., 2024)

scramb1⁴³ has embryonic/larval garland cell | larval stage phenotype, non-suppressible by Scer\GAL4^pros.PMG/scramb2^{UAS.ORF.GW.Tag:HA}

(Castillo-Mancho et al., 2024)

scramb1⁴³ has slit diaphragm | larval stage | absent phenotype, non-suppressible by Scer\GAL4^pros.PMG/scramb2^{UAS.ORF.GW.Tag:HA}

(Castillo-Mancho et al., 2024)

scramb1⁴³ has embryonic/larval garland cell | larval stage phenotype, non-suppressible by Scer\GAL4^pros.PMG/scramb1::scramb2^UAS.Tag:V5

(Castillo-Mancho et al., 2024)

scramb1⁴³ has slit diaphragm | larval stage | absent phenotype, non-suppressible by Scer\GAL4^pros.PMG/scramb1::scramb2^UAS.Tag:V5

(Castillo-Mancho et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

scramb1⁴³ is rescued by Scer\GAL4^pros.PMG/scramb1^{D372A.UAS.A.Tag:V5}

(Castillo-Mancho et al., 2024)

scramb1⁴³ is rescued by scramb1^{F374A.UAS.A.Tag:V5}/Scer\GAL4^pros.PMG

(Castillo-Mancho et al., 2024)

scramb1⁴³ is rescued by Scer\GAL4^pros.PMG/scramb1^{UAS.A.Tag:CS(TEVp),Tag:proteinA}

(Castillo-Mancho et al., 2024)

scramb1⁴³ is rescued by Scer\GAL4^pros.PMG/scramb1^UAS.A.Tag:V5

(Castillo-Mancho et al., 2024)

Partially rescued by

scramb1⁴³ is partially rescued by Scer\GAL4^pros.PMG/scramb1^{F378A.UAS.A.Tag:V5}

(Castillo-Mancho et al., 2024)

Not rescued by

scramb1⁴³ is not rescued by Scer\GAL4^pros.PMG/scramb1^{3NP.UAS.A.Tag:V5}

(Castillo-Mancho et al., 2024)

scramb1⁴³ is not rescued by Scer\GAL4^pros.PMG/scramb1^{D372A.F378A.UAS.A.Tag:V5}

(Castillo-Mancho et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

scramb1⁴³

(Castillo-Mancho et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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