FB2025_01 , released February 20, 2025
Gene Group: ESCRT-I COMPLEX
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General Information
Name
ESCRT-I COMPLEX
Species
D. melanogaster
Symbol
ESCRT-I
FlyBase ID
FBgg0000101
Date last reviewed
2022-11-03
Number of members
5
Description
Description
The ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is made up of five complexes ESCRT-0 to -III and the Vps4-Vta1 ATPase complex, which are sequentially recruited to the cytosolic face of the membrane, and mediate cargo recognition, membrane budding and fission. ESCRT-I is constitutive heterotetrameric complex. It interacts with ESCRT-O, -II and ubiquitin. Together with ESCRT-II, it mediates the formation of the membrane bud and stabilizes the neck region. (Adapted from PMID:22361144 and FBrf0209668).
Notes on Group

The yeast ESCRT-I component Vps37 has two homologs in D.mel - Vsp37A and Vps37B (FBrf0208194).

Source Material
The ESCRT-I COMPLEX Gene Group has been compiled using the following publication(s): Li and Blissard, 2015, Michelet et al., 2010, and Vaccari et al., 2009 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
endosome transport via multivesicular body sorting pathway
Cellular Component
ESCRT I complex
Related Gene Groups
Parent group(s)
ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT
Component group(s)
ESCRT-I COMPLEX VPS37A VARIANT
ESCRT-I COMPLEX VPS37B VARIANT
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
ESCRT-I COMPLEX VPS37A VARIANT
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Mvb12
Multivesicular body subunit 12
(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)
TSG101
Tumor susceptibility gene 101
ept, erupted, dTsg101, vps23, ESCRT-I
(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)
Vps28
Vacuolar protein sorting 28
l(2)k16503, dVps28
(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)
Vsp37A
Vacuolar protein sorting 37A
EG:115C2.5, mod(r), modifier of rudimentary
(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)
ESCRT-I COMPLEX VPS37B VARIANT
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Mvb12
Multivesicular body subunit 12
(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)
TSG101
Tumor susceptibility gene 101
ept, erupted, dTsg101, vps23, ESCRT-I
(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)
Vps28
Vacuolar protein sorting 28
l(2)k16503, dVps28
(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)
Vps37B
Vacuolar protein sorting 37B
(Li and Blissard, 2015, Michelet et al., 2010, Vaccari et al., 2009)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
ESCRT-I
ESCRT-I COMPLEX
Endosomal Sorting Complex Required for Transport I
ESCRT I
Secondary FlyBase ID(s)
References (4)