FB2025_01 , released February 20, 2025
Gene Group: PEROXIREDOXINS
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General Information
Name
PEROXIREDOXINS
Species
D. melanogaster
Symbol
PRXN
FlyBase ID
FBgg0001037
Date last reviewed
2022-05-25
Number of members
13
Description
Description
Peroxiredoxins are a family of thiol-dependent antioxidant proteins that catalyze the reduction of hydrogen peroxide, peroxynitrite and a wide range of organic hydroperoxides (ROOH) to the corresponding alcohol (ROH) and water. These proteins function as peroxidases only when coupled to a sulfhydryl-reducing system such as thioredoxin or glutathione. Catalytic activity is dependent on the oxidation of a conserved cysteine residue at the active site. (Adapted from FBrf0139661, PMID:12517450.)
Notes on Group

Prx5 is an atypical 2-Cys peroxiredoxin (FBrf0231274).

DJ-1α and dj-1β are predicted to encode atypical peroxiredoxin-like peroxidases, based on homology to mouse DJ-1 (Park7).

Gtpx and Gpxl encode the only two members of the glutathione peroxidase family in D. melanogaster, but they exhibit thioredoxin-dependent peroxiredoxin activity rather than glutathione peroxidase activity (FBrf0158751).

Source Material
The PEROXIREDOXINS Gene Group has been compiled using the following publication(s): McGinnis et al., 2021, Detienne et al., 2018, Edgar et al., 2012, Peterson and Luckhart, 2006, Missirlis et al., 2003, and Radyuk et al., 2001 .
Key Gene Ontology (GO) terms
Molecular Function
peroxiredoxin activity
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
PEROXIDASES
Members (13)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG12896
(FlyBase, 2017-, Edgar et al., 2012)
DJ-1α
DJ-1α
DJ-1, DJ-1A
(FlyBase, 2017-)
dj-1β
dj-1β
DJ-1, DJ-1b
(FlyBase, 2017-)
Gpxl
Glutathione peroxidase-like
(FlyBase, 2017-, Missirlis et al., 2003)
Gtpx
Glutathione peroxidase homolog with thioredoxin peroxidase activity
PHGPx, GPx, GTPx-1, glutathione peroxidase, glutathione peroxidase I
(FlyBase, 2017-, Missirlis et al., 2003)
Prx1
Peroxiredoxin 1
(McGinnis et al., 2021, FlyBase, 2017-, Edgar et al., 2012)
Prx2
Peroxiredoxin 2
Jafrac1, thioredoxin peroxidase 1, Jafrac, DPx4783, DPx-4783
(McGinnis et al., 2021, Detienne et al., 2018, FlyBase, 2017-, Edgar et al., 2012, Peterson and Luckhart, 2006, Radyuk et al., 2001)
Prx3
Peroxiredoxin 3
Prx5037, dPrx3, Peroxiredoxin 5037, DPx-5037, DPx5037
(McGinnis et al., 2021, Detienne et al., 2018, FlyBase, 2017-, Edgar et al., 2012, Peterson and Luckhart, 2006, Radyuk et al., 2001)
Prx4
Peroxiredoxin 4
Jafrac2, dPrx4, thioredoxin peroxidase 2, Jafrac, DPx4156
(McGinnis et al., 2021, Detienne et al., 2018, FlyBase, 2017-, Edgar et al., 2012, Peterson and Luckhart, 2006, Radyuk et al., 2001)
Prx5
Peroxiredoxin 5
dprx5, PRDX5
(Detienne et al., 2018, FlyBase, 2017-, Edgar et al., 2012, Peterson and Luckhart, 2006)
Prx6a
Peroxiredoxin 6a
Prx6005, DPx6005, Peroxiredoxin 6005
(Detienne et al., 2018, FlyBase, 2017-, Edgar et al., 2012, Peterson and Luckhart, 2006, Radyuk et al., 2001)
Prx6b
Peroxiredoxin 6b
Prx2540-1, Prx2540, peroxiredoxin 2540, Peroxiredoxin 2540-1, DPx-2540-1
(Detienne et al., 2018, FlyBase, 2017-, Edgar et al., 2012, Peterson and Luckhart, 2006, Radyuk et al., 2001)
Prx6c
Peroxiredoxin 6c
Prx2540-2, Peroxiredoxin 2540, Prx2540, DPx-2540-2
(Detienne et al., 2018, FlyBase, 2017-, Peterson and Luckhart, 2006, Radyuk et al., 2001)
External Data
Synonyms and Secondary IDs
Synonym(s)
PRXN
PEROXIREDOXINS
PRDX
PRX
Secondary FlyBase ID(s)
References (8)