The nucleotide-sugar GDP-D-mannose can be synthesized in the cytosol from D-mannose (though it is primarily produced from D-glucose). GDP-D-mannose is a precursor for GDP-L-fucose biosynthesis and protein glycosylation. (Adapted from PMID:24931670.)
GDP-MANNOSE BIOSYNTHESIS FROM MANNOSE
Notes
Hex-t1 and Hex-t2 are paralogs of Hex-A and Hex-C and are specifically expressed in testis. It is not clear if Hex-t1 is enzymatically active as the catalytic residue is not conserved. As there is no functional information, Hex-t1 and Hex-t2 are not included in the gene list.
Source Material
The
GDP-MANNOSE BIOSYNTHESIS FROM MANNOSE
Gene Group has been compiled using the following publication(s):
Parkinson et al., 2016
.
Note: The Drosophila pathways shown at these resources are computed using different methods.
They may therefore differ from the manually curated and verified pathway shown above.
