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| Citation | Wilanowski, T., Tuckfield, A., Cerruti, L., O'Connell, S., Saint, R., Parekh, V., Tao, J., Cunningham, J.M., Jane, S.M. (2002). A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech. Dev. 114(1-2): 37--50. (Export to RIS) | ||
| FlyBase ID | FBrf0150771 | ||
| Publication Type | Research paper | ||
| PubMed ID | 12175488 | ||
| PubMed Abstract | The Drosophila transcription factor Grainyhead regulates several key developmental processes. Three mammalian genes, CP2, LBP-1a and LBP-9 have been previously identified as homologues of grainyhead. We now report the cloning of two new mammalian genes (Mammalian grainyhead (MGR) and Brother-of-MGR (BOM)) and one new Drosophila gene (dCP2) that rewrite the phylogeny of this family. We demonstrate that MGR and BOM are more closely related to grh, whereas CP2, LBP-1a and LBP-9 are descendants of the dCP2 gene. MGR shares the greatest sequence homology with grh, is expressed in tissue-restricted patterns more comparable to grh and binds to and transactivates the promoter of the human Engrailed-1 gene, the mammalian homologue of the key grainyhead target gene, engrailed. This sequence and functional conservation indicates that the new mammalian members of this family play important developmental roles. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Mech. Dev. | ||
| Title | Mechanisms of Development | ||
| Publication Year | 1990- | ||
| ISBN/ISSN | 0925-4773 | ||
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Data from Reference
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