FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term cell cycle checkpoint signaling ID (Ontology) GO:0000075 (Gene Ontology)
Definition A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
Also Known As "cell cycle checkpoint" ; "signal transduction involved in cell cycle checkpoint" ; "signal transduction involved in G2/M transition checkpoint"
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signal transduction
 |__intracellular signal transduction___________________
negative regulation of cell cycle process               |
 |__negative regulation of cell cycle phase transition__|
regulation of cell cycle phase transition               |
 |__negative regulation of cell cycle phase transition__|
                                                        cell cycle checkpoint signaling  63 rec.
                                                         |__DNA integrity checkpoint signaling 44 rec.
                                                         |   |__DNA damage checkpoint signaling(+) 38 rec.
                                                         |   |__DNA replication checkpoint signaling(+) 18 rec.
                                                         |   |__meiotic DNA integrity checkpoint signaling(+) 1 rec.
                                                         |   |__mitotic DNA integrity checkpoint signaling(+) 29 rec.
                                                         |__meiotic cell cycle checkpoint signaling 4 rec.
                                                         |   |__meiotic DNA integrity checkpoint signaling(+) 1 rec.
                                                         |   |__meiotic recombination checkpoint signaling(+) 3 rec.
                                                         |   |__meiotic spindle checkpoint signaling(+) 1 rec.
                                                         |__mitotic cell cycle checkpoint signaling 45 rec.
                                                         |   |__mitotic cell size control checkpoint signaling(+)
                                                         |   |__mitotic cytokinesis checkpoint signaling 1 rec.
                                                         |   |__mitotic DNA integrity checkpoint signaling(+) 29 rec.
                                                         |   |__mitotic G1/S transition checkpoint signaling(+) 3 rec.
                                                         |   |__mitotic G2/M transition checkpoint(+) 20 rec.
                                                         |   |__mitotic morphogenesis checkpoint signaling
                                                         |   |__mitotic spindle checkpoint signaling(+) 13 rec.
                                                         |   |__signal transduction involved in cytokinesis checkpoint
                                                         |__regulation of cell cycle checkpoint 6 rec.
                                                         |   |__negative regulation of cell cycle checkpoint(+) 1 rec.
                                                         |   |__positive regulation of cell cycle checkpoint(+) 1 rec.
                                                         |   |__regulation of DNA damage checkpoint(+) 2 rec.
                                                         |   |__regulation of spindle checkpoint(+) 4 rec.
                                                         |__spindle checkpoint signaling 14 rec.
                                                             |__meiotic spindle checkpoint signaling(+) 1 rec.
                                                             |__mitotic spindle checkpoint signaling(+) 13 rec.
                                                             |__regulation of spindle checkpoint(+) 4 rec.
                                                             |__spindle assembly checkpoint signaling(+) 14 rec.
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Is a intracellular signal transduction
negative regulation of cell cycle phase transition
Part of
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Synonyms
  • "cell cycle checkpoint" EXACT
    "G1/S checkpoint" NARROW
    "G1/S transition checkpoint" NARROW
    "G2/M checkpoint" NARROW
    "G2/M transition checkpoint" NARROW
    "signal transduction involved in cell cycle checkpoint" EXACT
    "signal transduction involved in G2/M transition checkpoint" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-69620 "Cell Cycle Checkpoints"
Wikipedia:Cell_cycle_checkpoint