FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term MAPK cascade ID (Ontology) GO:0000165 (Gene Ontology)
Definition An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.[ PubMed:20811974 PubMed:9561267 ]
Also Known As "MAP kinase cascade" ; "MAP kinase kinase kinase cascade" ; "MAPK signal transduction" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      11
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 MAPK cascade (all annotations which use CV term, excluding "NOT" statements)       4     11
     involved_in | MAPK cascade       --      11
 NOT | involved_in | MAPK cascade       --       1
Spanning Tree (Parents/Children)
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  intracellular signal transduction
   |__intracellular signaling cassette
       |__MAPK cascade  167 rec.
           |__ERK1 and ERK2 cascade 49 rec.
           |   |__regulation of ERK1 and ERK2 cascade(+) 47 rec.
           |__ERK5 cascade
           |   |__regulation of ERK5 cascade(+)
           |__JNK cascade 86 rec.
           |   |__JUN phosphorylation
           |   |__regulation of JNK cascade(+) 72 rec.
           |__p38MAPK cascade 8 rec.
           |   |__regulation of p38MAPK cascade(+) 2 rec.
           |__pheromone response MAPK cascade
           |   |__regulation of pheromone response MAPK cascade(+)
           |__regulation of MAPK cascade 144 rec.
           |   |__negative regulation of MAPK cascade(+) 53 rec.
           |   |__positive regulation of MAPK cascade(+) 80 rec.
           |   |__regulation of ERK1 and ERK2 cascade(+) 47 rec.
           |   |__regulation of ERK5 cascade(+)
           |   |__regulation of JNK cascade(+) 72 rec.
           |   |__regulation of p38MAPK cascade(+) 2 rec.
           |   |__regulation of pheromone response MAPK cascade(+)
           |   |__regulation of stress-activated MAPK cascade(+) 4 rec.
           |__stress-activated MAPK cascade 5 rec.
               |__cell integrity MAPK cascade(+)
               |__filamentous growth MAPK cascade
               |__regulation of stress-activated MAPK cascade(+) 4 rec.
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Is a intracellular signaling cassette
Part of
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Synonyms
  • "ERK/MAPK cascade" NARROW
    "MAP kinase cascade" EXACT
    "MAP kinase kinase kinase cascade" EXACT
    "MAPK signal transduction" EXACT
    "MAPK signaling" RELATED
    "MAPK signalling" RELATED
    "MAPKKK cascade" EXACT
    "MAPKKK cascade during sporulation" NARROW
    "mitogen-activated protein kinase cascade" EXACT
Secondary IDs
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Reactome:R-HSA-169893 "Prolonged ERK activation events"
Reactome:R-HSA-5673001 "RAF/MAP kinase cascade"
Wikipedia:MAPK_cascade
Wikipedia:Mitogen-activated_protein_kinase