FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ID (Ontology) GO:0000288 (Gene Ontology)
Definition A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
Also Known As "deadenylation-dependent mRNA decay" ; "mRNA breakdown, deadenylation-dependent decay" ; "mRNA catabolic process, deadenylation-dependent" (for all, see Synonyms field below)
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       7
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (all annotations which use CV term, excluding "NOT" statements)       7
     involved_in | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay       7
Spanning Tree (Parents/Children)
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mRNA catabolic process
 |__nuclear-transcribed mRNA catabolic process__
negative regulation of gene expression          |
 |__mRNA destabilization________________________|
regulation of mRNA stability                    |
 |__mRNA destabilization________________________|
RNA destabilization                             |
 |__mRNA destabilization________________________|
positive regulation of mRNA catabolic process   |
 |__mRNA destabilization________________________|
                                                nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  26 rec.
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Is a nuclear-transcribed mRNA catabolic process
mRNA destabilization
Part of
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Synonyms
  • "deadenylation-dependent mRNA decay" EXACT
    "mRNA breakdown, deadenylation-dependent decay" EXACT
    "mRNA catabolic process, deadenylation-dependent" EXACT
    "mRNA catabolic process, deadenylylation-dependent" EXACT
    "mRNA catabolism, deadenylation-dependent" EXACT
    "mRNA catabolism, deadenylylation-dependent" EXACT
    "mRNA degradation, deadenylation-dependent decay" EXACT
    "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT
Secondary IDs
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Reactome:R-HSA-429914 "Deadenylation-dependent mRNA decay"