FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term Hrd1p ubiquitin ligase complex ID (Ontology) GO:0000836 (Gene Ontology)
Definition A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78).[ PubMed:16619026 PubMed:16873066 PubMed:21454652 ]
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       1
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 Genes
 Hrd1p ubiquitin ligase complex (all annotations which use CV term, excluding "NOT" statements)       1
     part_of | Hrd1p ubiquitin ligase complex       1
Spanning Tree (Parents/Children)
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cytoplasmic ubiquitin ligase complex______________
membrane protein complex__________________________|
endoplasmic reticulum protein-containing complex__|
                                                  ER ubiquitin ligase complex
                                                   |__Hrd1p ubiquitin ligase complex  1 rec.
                                                       |__Hrd1p ubiquitin ligase ERAD-L complex
                                                       |__Hrd1p ubiquitin ligase ERAD-M complex
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Is a ER ubiquitin ligase complex
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Synonyms
  • "HRD1 ubiquitin ligase complex" RELATED
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