FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term epithelial to mesenchymal transition ID (Ontology) GO:0001837 (Gene Ontology)
Definition A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.[ PubMed:14701881 ]
Also Known As "EMT" ; "epithelial-mesenchymal transition" ; "mesenchymal cell differentiation from epithelial cell"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       5
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 epithelial to mesenchymal transition (all annotations which use CV term, excluding "NOT" statements)       5
     acts_upstream_of_negative_effect | epithelial to mesenchymal transition       1
     involved_in | epithelial to mesenchymal transition       4
Spanning Tree (Parents/Children)
Only view relationship: 
cell differentiation____
mesenchyme development__|
                        mesenchymal cell differentiation
                         |__epithelial to mesenchymal transition  5 rec.
                             |__cardiac epithelial to mesenchymal transition
                             |   |__endocardial cushion to mesenchymal transition(+)
                             |   |__epithelial to mesenchymal transition involved in cardiac fibroblast development
                             |   |__epithelial to mesenchymal transition involved in coronary vasculature morphogenesis
                             |   |__epithelial to mesenchymal transition involved in endocardial cushion formation(+)
                             |   |__regulation of cardiac epithelial to mesenchymal transition(+)
                             |__clearance of cells from fusion plate by epithelial to mesenchymal transition
                             |__epicardial cell to mesenchymal cell transition
                             |__mesodermal to mesenchymal transition involved in gastrulation
                             |__neural crest formation
                             |   |__neural crest cell fate commitment(+)
                             |   |__regulation of neural crest formation(+)
                             |__regulation of epithelial to mesenchymal transition
                                 |__negative regulation of epithelial to mesenchymal transition(+)
                                 |__positive regulation of epithelial to mesenchymal transition(+)
                                 |__regulation of cardiac epithelial to mesenchymal transition(+)
                                 |__regulation of neural crest formation(+)
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a mesenchymal cell differentiation
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "EMT" EXACT
    "epithelial-mesenchymal transition" EXACT
    "mesenchymal cell differentiation from epithelial cell" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-9758919 "Epithelial-Mesenchymal Transition (EMT) during gastrulation"