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General Information
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| Term |
marginal zone B cell differentiation |
ID (Ontology) |
GO:0002315 (Gene Ontology) |
| Definition |
The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).[ ISBN:0781735149 ] |
| Also Known As |
"marginal zone B lymphocyte differentiation" ; "marginal zone B-cell differentiation" ; "marginal zone B-lymphocyte differentiation" |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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No relevant records available
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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No relevant statements available
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Relationships
