immune system process__
gene expression________|
                       production of molecular mediator of immune response
                        |__immunoglobulin production
                            |__immunoglobulin production involved in immunoglobulin-mediated immune response
                            |   |__B cell affinity maturation(+)
                            |   |__immunoglobulin production in mucosal tissue(+)
                            |   |__somatic diversification of immunoglobulins involved in immune response(+)
                            |__regulation of immunoglobulin production
                            |   |__negative regulation of immunoglobulin production(+)
                            |   |__positive regulation of immunoglobulin production(+)
                            |   |__regulation of immunoglobulin production in mucosal tissue(+)
                            |   |__regulation of isotype switching(+)
                            |__somatic diversification of immunoglobulins
                                |__alternate splicing of immunoglobulin genes
                                |__gene conversion of immunoglobulin genes(+)
                                |__somatic diversification of immunoglobulin genes by N region addition
                                |__somatic diversification of immunoglobulins involved in immune response(+)
                                |__somatic hypermutation of immunoglobulin genes(+)
                                |__somatic recombination of immunoglobulin gene segments(+)