FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
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Term antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent ID (Ontology) GO:0002479 (Gene Ontology)
Definition The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.[ PubMed:15224093 PubMed:15771591 PubMed:16181335 ]
Also Known As "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" ; "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" ; "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I"
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antigen processing and presentation of peptide antigen via MHC class I__
antigen processing and presentation of exogenous peptide antigen________|
                                                                        antigen processing and presentation of exogenous peptide antigen via MHC class I
                                                                         |__antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
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Is a antigen processing and presentation of exogenous peptide antigen via MHC class I
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Synonyms
  • "cross presentation" BROAD
    "cross-presentation" BROAD
    "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT
    "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT
    "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT
Secondary IDs
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Reactome:R-HSA-1236973 "Cross-presentation of particulate exogenous antigens (phagosomes)"
Reactome:R-HSA-1236974 "ER-Phagosome pathway"
Reactome:R-HSA-1236978 "Cross-presentation of soluble exogenous antigens (endosomes)"