FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term MyD88-dependent toll-like receptor signaling pathway ID (Ontology) GO:0002755 (Gene Ontology)
Definition A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.[ ISBN:0781735149 PubMed:12467241 PubMed:12524386 PubMed:12855817 PubMed:15585605 PubMed:15728447 ]
Also Known As "MyD88-dependent TLR signaling pathway" ; "MyD88-dependent toll-like receptor signalling pathway"
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  pattern recognition receptor signaling pathway
   |__toll-like receptor signaling pathway
       |__MyD88-dependent toll-like receptor signaling pathway
           |__MyD88-dependent toll-like receptor 2 signaling pathway
           |__MyD88-dependent toll-like receptor 4 signaling pathway
           |__regulation of MyD88-dependent toll-like receptor signaling pathway
               |__negative regulation of MyD88-dependent toll-like receptor signaling pathway
               |__positive regulation of MyD88-dependent toll-like receptor signaling pathway
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Is a toll-like receptor signaling pathway
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Synonyms
  • "MyD88-dependent TLR signaling pathway" EXACT
    "MyD88-dependent toll-like receptor signalling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-166058 "MyD88:MAL(TIRAP) cascade initiated on plasma membrane"
Reactome:R-HSA-975871 "MyD88 cascade initiated on plasma membrane"