FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term MyD88-independent toll-like receptor signaling pathway ID (Ontology) GO:0002756 (Gene Ontology)
Definition A toll-like receptor signaling pathway not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate an immune response.[ ISBN:0781735149 PubMed:12467241 PubMed:12524386 PubMed:12855817 PubMed:15585605 PubMed:15728447 ]
Also Known As "MyD88-independent TLR signaling pathway" ; "MyD88-independent toll-like receptor signalling pathway"
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  pattern recognition receptor signaling pathway
   |__toll-like receptor signaling pathway
       |__MyD88-independent toll-like receptor signaling pathway
           |__TRAM-dependent toll-like receptor signaling pathway
           |   |__TRAM-dependent toll-like receptor 4 signaling pathway
           |__TRIF-dependent toll-like receptor signaling pathway
               |__TRIF-dependent toll-like receptor 4 signaling pathway
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Is a toll-like receptor signaling pathway
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Synonyms
  • "MyD88-independent TLR signaling pathway" EXACT
    "MyD88-independent toll-like receptor signalling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-166166 "MyD88-independent TLR4 cascade"
Reactome:R-HSA-168927 "TICAM1, RIP1-mediated IKK complex recruitment"