| General Information | |||
|---|---|---|---|
| Term | pyruvate decarboxylation to acetyl-CoA | ID (Ontology) | GO:0006086 (Gene Ontology) |
| Definition | The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: pyruvate + coenzyme A + NAD+ -> acetyl-CoA + CO2 + NADH. | ||
| Also Known As | "acetyl-CoA anabolism from pyruvate" ; "acetyl-CoA biosynthetic process from pyruvate" ; "acetyl-CoA formation from pyruvate" (for all, see Synonyms field below) | ||
| Comment | |||
| Links to External Ontologies | |||
| QuickGO data AmiGO data | |||
| Annotations | |||
| Records annotated with this term OR any of its CHILD TERMS | |||
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
|
|||
acetyl-CoA metabolic process |__acetyl-CoA biosynthetic process____ monocarboxylic acid metabolic process | |__pyruvate metabolic process_________| acyl-CoA biosynthetic process | |__acetyl-CoA biosynthetic process____| pyruvate decarboxylation to acetyl-CoA 13 rec. |
| Spanning Tree View Settings | |||
|---|---|---|---|
| Parents/Children View Depth |
|||
Relationships
|
|||
| Is a |
acetyl-CoA biosynthetic process pyruvate metabolic process |
||
| Part of | aerobic respiration | ||
Synonyms & Secondary IDs
|
|||
| Synonyms | |||
|
|||
| Secondary IDs | |||
|
|
|||
External Crossreferences & Linkouts
|
|||
|
MetaCyc:PYRUVDEHYD-PWY Reactome:R-HSA-9861559 "PDH complex synthesizes acetyl-CoA from PYR" |
|||