FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term pyruvate decarboxylation to acetyl-CoA ID (Ontology) GO:0006086 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: pyruvate + coenzyme A + NAD+ -> acetyl-CoA + CO2 + NADH.
Also Known As "acetyl-CoA anabolism from pyruvate" ; "acetyl-CoA biosynthetic process from pyruvate" ; "acetyl-CoA formation from pyruvate" (for all, see Synonyms field below)
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       5
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 pyruvate decarboxylation to acetyl-CoA (all annotations which use CV term, excluding "NOT" statements)       5      5
     involved_in | pyruvate decarboxylation to acetyl-CoA       --       5
Spanning Tree (Parents/Children)
Only view relationship:
acetyl-CoA metabolic process
 |__acetyl-CoA biosynthetic process____
monocarboxylic acid metabolic process  |
 |__pyruvate metabolic process_________|
acyl-CoA biosynthetic process          |
 |__acetyl-CoA biosynthetic process____|
                                       pyruvate decarboxylation to acetyl-CoA  13 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a acetyl-CoA biosynthetic process
pyruvate metabolic process
Part of aerobic respiration
hide Synonyms & Secondary IDs
Synonyms
  • "acetyl-CoA anabolism from pyruvate" EXACT
    "acetyl-CoA biosynthetic process from pyruvate" EXACT
    "acetyl-CoA formation from pyruvate" EXACT
    "acetyl-CoA synthesis from pyruvate" EXACT
    "oxidative decarboxylation of pyruvate" EXACT
    "pyruvate decarboxylation" NARROW
    "pyruvate dehydrogenase pathway" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
MetaCyc:PYRUVDEHYD-PWY
Reactome:R-HSA-9861559 "PDH complex synthesizes acetyl-CoA from PYR"