FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term DNA repair ID (Ontology) GO:0006281 (Gene Ontology)
Definition The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.[ PubMed:11563486 ]
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      88
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Relevant FlyBase reports
 Gene Groups Genes
 DNA repair (all annotations which use CV term, excluding "NOT" statements)       6     88
     involved_in | DNA repair       --      85
Spanning Tree (Parents/Children)
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cellular response to stress
 |__DNA damage response_________
nucleic acid metabolic process  |
 |__DNA metabolic process_______|
                                DNA repair  213 rec.
                                 |__base-excision repair 14 rec.
                                 |   |__telomere maintenance via base-excision repair
                                 |__chromosomal 5-methylcytosine DNA demethylation, oxidative deamination pathway
                                 |__DNA alkylation repair 2 rec.
                                 |__DNA replication proofreading 7 rec.
                                 |__double-strand break repair 109 rec.
                                 |   |__double-strand break repair involved in meiotic recombination 2 rec.
                                 |   |__double-strand break repair via homologous recombination(+) 66 rec.
                                 |   |__double-strand break repair via nonhomologous end joining(+) 11 rec.
                                 |   |__double-strand break repair via single-strand annealing 5 rec.
                                 |   |__mitochondrial double-strand break repair(+) 1 rec.
                                 |__interstrand cross-link repair 16 rec.
                                 |   |__non-recombinational interstrand cross-link repair
                                 |   |__recombinational interstrand cross-link repair
                                 |__mismatch repair 14 rec.
                                 |   |__meiotic mismatch repair(+) 2 rec.
                                 |   |__mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication(+)
                                 |__mitochondrial DNA repair 1 rec.
                                 |__non-photoreactive DNA repair
                                 |__nucleotide-excision repair 28 rec.
                                 |   |__global genome nucleotide-excision repair
                                 |   |__nucleotide-excision repair involved in interstrand cross-link repair 3 rec.
                                 |   |__pyrimidine dimer repair by nucleotide-excision repair
                                 |   |__transcription-coupled nucleotide-excision repair 1 rec.
                                 |__protein-DNA covalent cross-linking repair 3 rec.
                                 |__pyrimidine dimer repair 2 rec.
                                 |   |__photoreactive repair 2 rec.
                                 |   |__pyrimidine dimer repair by nucleotide-excision repair
                                 |__recombinational repair 66 rec.
                                 |   |__double-strand break repair via homologous recombination(+) 66 rec.
                                 |   |__mitochondrial double-strand break repair via homologous recombination 1 rec.
                                 |   |__recombinational interstrand cross-link repair
                                 |   |__single-strand break repair via homologous recombination
                                 |__single strand break repair 3 rec.
                                 |   |__single-strand break repair via homologous recombination
                                 |   |__telomere single strand break repair
                                 |__UV-damage excision repair 3 rec.
                                 |__viral DNA repair
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Is a DNA metabolic process
DNA damage response
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Reactome:R-HSA-73894 "DNA Repair"
Wikipedia:DNA_repair