FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term mRNA catabolic process ID (Ontology) GO:0006402 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.[ ISBN:0198506732 ]
Also Known As "mRNA breakdown" ; "mRNA catabolism" ; "mRNA degradation"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      23
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 mRNA catabolic process (all annotations which use CV term, excluding "NOT" statements)       1     23
     involved_in | mRNA catabolic process       --      23
Spanning Tree (Parents/Children)
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regulation of gene expression
 |__negative regulation of gene expression_________________
negative regulation of macromolecule biosynthetic process  |
 |__negative regulation of gene expression_________________|
RNA metabolic process                                      |
 |__RNA catabolic process__________________________________|
 |__mRNA metabolic process_________________________________|
nucleic acid catabolic process                             |
 |__RNA catabolic process__________________________________|
                                                           mRNA catabolic process  138 rec.
                                                            |__maternal mRNA clearance 3 rec.
                                                            |__mitochondrial mRNA catabolic process 4 rec.
                                                            |   |__mitochondrial mRNA surveillance
                                                            |   |__regulation of mitochondrial mRNA catabolic process(+) 2 rec.
                                                            |__nuclear-transcribed mRNA catabolic process 65 rec.
                                                            |   |__deadenylation-dependent decapping of nuclear-transcribed mRNA(+) 7 rec.
                                                            |   |__histone mRNA catabolic process(+) 1 rec.
                                                            |   |__nuclear mRNA surveillance(+) 8 rec.
                                                            |   |__nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(+) 26 rec.
                                                            |   |__nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(+) 6 rec.
                                                            |   |__nuclear-transcribed mRNA catabolic process, no-go decay 1 rec.
                                                            |   |__nuclear-transcribed mRNA catabolic process, non-stop decay 3 rec.
                                                            |   |__nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(+) 18 rec.
                                                            |   |__nuclear-transcribed mRNA catabolic process, RNase MRP-dependent
                                                            |   |__nuclear-transcribed mRNA poly(A) tail shortening(+) 17 rec.
                                                            |__polyadenylation-dependent mRNA catabolic process
                                                            |   |__nuclear polyadenylation-dependent mRNA catabolic process
                                                            |__polyuridylation-dependent mRNA catabolic process
                                                            |   |__polyuridylation-dependent decapping of nuclear-transcribed mRNA
                                                            |__regulation of mRNA catabolic process 87 rec.
                                                                |__negative regulation of mRNA catabolic process(+) 11 rec.
                                                                |__positive regulation of mRNA catabolic process(+) 69 rec.
                                                                |__regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA(+)
                                                                |__regulation of mitochondrial mRNA catabolic process(+) 2 rec.
                                                                |__regulation of mRNA stability(+) 84 rec.
                                                                |__regulation of nuclear mRNA surveillance of meiosis-specific transcripts(+)
                                                                |__regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(+) 1 rec.
                                                                |__regulation of nuclear-transcribed mRNA poly(A) tail shortening(+) 6 rec.
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Is a RNA catabolic process
negative regulation of gene expression
mRNA metabolic process
Part of
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Synonyms
  • "mRNA breakdown" EXACT
    "mRNA catabolism" EXACT
    "mRNA decay" RELATED
    "mRNA degradation" EXACT
Secondary IDs
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