FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term translational initiation ID (Ontology) GO:0006413 (Gene Ontology)
Definition The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
Also Known As "translation initiation"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      48
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 translational initiation (all annotations which use CV term, excluding "NOT" statements)      48
     involved_in | translational initiation      48
Spanning Tree (Parents/Children)
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macromolecule biosynthetic process
 |__translation_______________
cellular process              |
 |__metabolic process_________|
protein metabolic process     |
 |__translation_______________|
protein biosynthetic process  |
 |__translation_______________|
                              translational initiation  85 rec.
                               |__cytoplasmic translational initiation 22 rec.
                               |   |__cap-dependent translational initiation(+)
                               |   |__cap-independent translational initiation(+) 1 rec.
                               |   |__formation of cytoplasmic translation initiation complex 3 rec.
                               |   |__formation of translation preinitiation complex(+) 8 rec.
                               |   |__regulation of cytoplasmic translational initiation(+) 2 rec.
                               |   |__translation reinitiation 6 rec.
                               |__formation of translation initiation ternary complex 1 rec.
                               |   |__regulation of formation of translation initiation ternary complex(+) 1 rec.
                               |__mitochondrial translational initiation 3 rec.
                               |   |__regulation of mitochondrial translational initiation(+)
                               |__regulation of translational initiation 32 rec.
                                   |__negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
                                   |__negative regulation of translational initiation(+) 14 rec.
                                   |__positive regulation of translational initiation(+) 5 rec.
                                   |__regulation of cytoplasmic translational initiation(+) 2 rec.
                                   |__regulation of eIF2 alpha phosphorylation by dsRNA
                                   |__regulation of eIF2 alpha phosphorylation by heme
                                   |__regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
                                   |__regulation of mitochondrial translational initiation(+)
                                   |__regulation of translational initiation by iron(+)
                                   |__regulation of translational initiation by tRNA modification
                                   |__regulation of translational initiation in response to stress(+)
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Is a metabolic process
Part of translation
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Synonyms
  • "biopolymerisation" BROAD
    "biopolymerization" BROAD
    "protein synthesis initiation" BROAD
    "translation initiation" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-72613 "Eukaryotic Translation Initiation"