FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term protein folding ID (Ontology) GO:0006457 (Gene Ontology)
Definition The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
Comment
Links to External Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS     121
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 protein folding (all annotations which use CV term, excluding "NOT" statements)      13    121
     involved_in | protein folding       --     121
Spanning Tree (Parents/Children)
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biological_process
 |__cellular process_______
gene expression            |
 |__protein maturation_____|
protein metabolic process  |
 |__protein maturation_____|
                           protein folding  157 rec.
                            |__'de novo' protein folding 3 rec.
                            |   |__'de novo' cotranslational protein folding 2 rec.
                            |   |__'de novo' post-translational protein folding
                            |__mitochondrial disulfide relay system 4 rec.
                            |__post-chaperonin tubulin folding pathway 7 rec.
                            |__protein folding in endoplasmic reticulum 4 rec.
                            |   |__regulation of protein folding in endoplasmic reticulum
                            |__protein refolding 33 rec.
                            |   |__regulation of protein refolding(+)
                            |__regulation of protein folding
                                |__negative regulation of protein folding(+)
                                |__positive regulation of protein folding(+)
                                |__regulation of protein folding in endoplasmic reticulum
                                |__regulation of protein refolding(+)
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Is a cellular process
Part of protein maturation
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Synonyms
  • "alpha-tubulin folding" NARROW
    "beta-tubulin folding" NARROW
    "chaperone activity" RELATED
    "chaperonin ATPase activity" RELATED
    "chaperonin-mediated tubulin folding" NARROW
    "co-chaperone activity" RELATED
    "co-chaperonin activity" RELATED
    "glycoprotein-specific chaperone activity" RELATED
    "non-chaperonin molecular chaperone ATPase activity" RELATED
    "protein complex assembly, multichaperone pathway" RELATED
Secondary IDs
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Reactome:R-HSA-389960 "Formation of tubulin folding intermediates by CCT/TriC"
Reactome:R-HSA-390466 "Chaperonin-mediated protein folding"
Reactome:R-HSA-532668 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
Wikipedia:Protein_folding