FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term proteolysis ID (Ontology) GO:0006508 (Gene Ontology)
Definition The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
Also Known As "peptidolysis"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS     496
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 proteolysis (all annotations which use CV term, excluding "NOT" statements)      56    496
     involved_in | proteolysis       --     488
 NOT | involved_in | proteolysis       --       6
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macromolecule metabolic process__
primary metabolic process________|
                                 protein metabolic process
                                  |__proteolysis  1017 rec.
                                      |__membrane protein proteolysis 15 rec.
                                      |   |__membrane protein ectodomain proteolysis(+) 11 rec.
                                      |   |__membrane protein intracellular domain proteolysis(+) 5 rec.
                                      |   |__membrane protein proteolysis involved in retrograde protein transport, ER to cytosol
                                      |__protein processing 97 rec.
                                      |   |__activation of plasma proteins involved in acute inflammatory response
                                      |   |__CAAX-box protein processing 7 rec.
                                      |   |__dibasic protein processing(+)
                                      |   |__mitochondrial protein processing(+) 10 rec.
                                      |   |__Notch receptor processing, ligand-independent
                                      |   |__protein autoprocessing 6 rec.
                                      |   |__protein processing in phagocytic vesicle(+)
                                      |   |__protein splicing(+) 1 rec.
                                      |   |__regulation of protein processing(+) 5 rec.
                                      |   |__signal peptide processing(+) 9 rec.
                                      |   |__signaling receptor ligand precursor processing(+) 20 rec.
                                      |   |__vacuolar protein processing 1 rec.
                                      |   |__zymogen activation(+) 9 rec.
                                      |__proteolysis involved in protein catabolic process 416 rec.
                                      |   |__acrosome matrix dispersal
                                      |   |__membrane protein proteolysis involved in retrograde protein transport, ER to cytosol
                                      |   |__modification-dependent protein catabolic process(+) 362 rec.
                                      |   |__proteasomal protein catabolic process(+) 314 rec.
                                      |   |__protein quality control for misfolded or incompletely synthesized proteins(+) 11 rec.
                                      |   |__proteolysis associated with antigen processing and presentation(+)
                                      |   |__regulation of proteolysis involved in protein catabolic process(+) 82 rec.
                                      |   |__ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway 1 rec.
                                      |__regulation of proteolysis 121 rec.
                                      |   |__negative regulation of proteolysis(+) 44 rec.
                                      |   |__positive regulation of proteolysis(+) 63 rec.
                                      |   |__regulation of membrane protein ectodomain proteolysis(+) 1 rec.
                                      |   |__regulation of peptidase activity(+) 2 rec.
                                      |   |__regulation of protein processing(+) 5 rec.
                                      |   |__regulation of proteolysis involved in protein catabolic process(+) 82 rec.
                                      |__self proteolysis 1 rec.
                                          |__calcium-dependent self proteolysis
                                          |__sodium-dependent self proteolysis
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Is a protein metabolic process
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Synonyms
  • "ATP-dependent proteolysis" NARROW
    "peptidolysis" EXACT
Secondary IDs
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Wikipedia:Proteolysis