General Information
Term	gamma-aminobutyrate shunt	ID (Ontology)	GO:0006540 (Gene Ontology)
Definition	The chemical reactions and pathways resulting in the formation of succinate from L-glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.[ PubMed:12740438 ]
Also Known As	"4-aminobutyrate shunt" ; "degradation of glutamate to succinate through GABA" ; "GABA shunt" (for all, see Synonyms field below)
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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General Information

Term

gamma-aminobutyrate shunt

ID (Ontology)

GO:0006540 (Gene Ontology)

Definition

The chemical reactions and pathways resulting in the formation of succinate from L-glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.[ PubMed:12740438 ]

Also Known As

"4-aminobutyrate shunt" ; "degradation of glutamate to succinate through GABA" ; "GABA shunt" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

glutamate metabolic process
 |__L-glutamate catabolic process___________
dicarboxylic acid metabolic process         |
 |__succinate metabolic process_____________|
dicarboxylic acid catabolic process         |
 |__L-glutamate catabolic process___________|
L-amino acid catabolic process              |
 |__L-glutamate catabolic process___________|
proteinogenic amino acid catabolic process  |
 |__L-glutamate catabolic process___________|
                                            gamma-aminobutyrate shunt

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Is a	succinate metabolic process L-glutamate catabolic process
Part of
Synonyms & Secondary IDs
Synonyms
	"4-aminobutyrate shunt" EXACT "degradation of glutamate to succinate through GABA" EXACT "GABA shunt" EXACT "gamma aminobutyrate shunt" EXACT "glutamate decarboxylation to succinate" EXACT "glutamate degradation via 4-aminobutyrate" EXACT "glutamate degradation via GABA" EXACT
Secondary IDs

External Crossreferences & Linkouts
	MetaCyc:GLUDEG-I-PWY

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Is a

succinate metabolic process
L-glutamate catabolic process

Part of

Synonyms & Secondary IDs

Synonyms

"4-aminobutyrate shunt" EXACT
"degradation of glutamate to succinate through GABA" EXACT
"GABA shunt" EXACT
"gamma aminobutyrate shunt" EXACT
"glutamate decarboxylation to succinate" EXACT
"glutamate degradation via 4-aminobutyrate" EXACT
"glutamate degradation via GABA" EXACT

Secondary IDs

External Crossreferences & Linkouts

MetaCyc:GLUDEG-I-PWY