FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term apoptotic process ID (Ontology) GO:0006915 (Gene Ontology)
Definition A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.[ ISBN:0198506732 PubMed:18846107 PubMed:21494263 ]
Also Known As "apoptotic cell death" ; "apoptotic programmed cell death" ; "programmed cell death by apoptosis"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      65
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 apoptotic process (all annotations which use CV term, excluding "NOT" statements)       1     65
     acts_upstream_of_positive_effect | apoptotic process       --       1
     involved_in | apoptotic process       --      64
Spanning Tree (Parents/Children)
Only view relationship:
  cell death
   |__programmed cell death
       |__apoptotic process  303 rec.
           |__anoikis
           |__apoptotic process in bone marrow cell
           |__apoptotic process in response to mitochondrial fragmentation
           |__apoptotic process involved in development 25 rec.
           |   |__apoptotic process involved in luteolysis
           |   |__apoptotic process involved in metanephric collecting duct development
           |   |__apoptotic process involved in metanephric nephron tubule development
           |   |__apoptotic process involved in morphogenesis(+) 3 rec.
           |   |__B cell deletion(+)
           |   |__mesenchymal cell apoptotic process involved in metanephros development(+)
           |   |__nurse cell apoptotic process 18 rec.
           |__endothelial cell apoptotic process
           |__epithelial cell apoptotic process
           |   |__cholangiocyte apoptotic process
           |   |__epithelial cell apoptotic process involved in palatal shelf morphogenesis
           |   |__granulosa cell apoptotic process
           |   |__hepatocyte apoptotic process
           |   |__keratinocyte apoptotic process
           |   |__lens fiber cell apoptotic process
           |   |__podocyte apoptotic process
           |   |__Sertoli cell apoptotic process
           |   |__type B pancreatic cell apoptotic process
           |__fat cell apoptotic process
           |__fibroblast apoptotic process
           |__glial cell apoptotic process 4 rec.
           |   |__oligodendrocyte apoptotic process
           |__hepatoblast apoptotic process
           |__inflammatory cell apoptotic process
           |   |__macrophage apoptotic process
           |   |__neutrophil apoptotic process
           |__leukocyte apoptotic process
           |   |__dendritic cell apoptotic process
           |   |__lymphocyte apoptotic process(+)
           |   |__macrophage apoptotic process
           |   |__mast cell apoptotic process
           |   |__neutrophil apoptotic process
           |__melanocyte apoptotic process
           |__mesenchymal cell apoptotic process
           |   |__mesenchymal cell apoptotic process involved in metanephros development(+)
           |   |__mesenchymal cell apoptotic process involved in nephron morphogenesis(+)
           |__muscle cell apoptotic process
           |   |__smooth muscle cell apoptotic process(+)
           |   |__striated muscle cell apoptotic process(+)
           |__myeloid cell apoptotic process
           |   |__erythrocyte apoptotic process
           |   |__macrophage apoptotic process
           |   |__mast cell apoptotic process
           |   |__neutrophil apoptotic process
           |__myofibroblast cell apoptotic process
           |__neuron apoptotic process 37 rec.
           |   |__hippocampal neuron apoptotic process
           |   |__motor neuron apoptotic process 1 rec.
           |   |__outer hair cell apoptotic process
           |   |__retinal cone cell apoptotic process
           |   |__retinal rod cell apoptotic process
           |__retinal cell apoptotic process 2 rec.
               |__compound eye retinal cell apoptotic process 2 rec.
               |__retinal cone cell apoptotic process
               |__retinal rod cell apoptotic process
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a programmed cell death
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "activation of apoptosis" NARROW
    "apoptosis" NARROW
    "apoptosis activator activity" RELATED
    "apoptosis signaling" NARROW
    "apoptotic cell death" EXACT
    "apoptotic program" NARROW
    "apoptotic programmed cell death" EXACT
    "caspase-dependent programmed cell death" RELATED
    "cell suicide" BROAD
    "cellular suicide" BROAD
    "commitment to apoptosis" RELATED
    "induction of apoptosis" RELATED
    "induction of apoptosis by p53" RELATED
    "programmed cell death by apoptosis" EXACT
    "signaling (initiator) caspase activity" RELATED
    "type I programmed cell death" NARROW
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-109581 "Apoptosis"
Wikipedia:Apoptosis