FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term cell surface receptor protein tyrosine kinase signaling pathway ID (Ontology) GO:0007169 (Gene Ontology)
Definition The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
Also Known As "transmembrane receptor protein tyrosine kinase signalling pathway"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      24
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 cell surface receptor protein tyrosine kinase signaling pathway (all annotations which use CV term, excluding "NOT" statements)      24
     involved_in | cell surface receptor protein tyrosine kinase signaling pathway      24
Spanning Tree (Parents/Children)
Only view relationship:
  cell surface receptor signaling pathway
   |__enzyme-linked receptor protein signaling pathway
       |__cell surface receptor protein tyrosine kinase signaling pathway  254 rec.
           |__brain-derived neurotrophic factor receptor signaling pathway
           |__collagen-activated tyrosine kinase receptor signaling pathway
           |__ephrin receptor signaling pathway 4 rec.
           |__ERBB signaling pathway 85 rec.
           |   |__epidermal growth factor receptor signaling pathway(+) 85 rec.
           |   |__ERBB2 signaling pathway(+)
           |   |__ERBB3 signaling pathway(+)
           |   |__ERBB4 signaling pathway(+)
           |__fibroblast growth factor receptor signaling pathway 43 rec.
           |   |__fibroblast growth factor receptor apoptotic signaling pathway
           |   |__fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division
           |   |__fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment
           |   |__fibroblast growth factor receptor signaling pathway involved in heart development
           |   |__fibroblast growth factor receptor signaling pathway involved in hemopoiesis
           |   |__fibroblast growth factor receptor signaling pathway involved in mammary gland specification
           |   |__fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
           |   |__fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(+)
           |   |__fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
           |   |__fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
           |   |__fibroblast growth factor receptor signaling pathway involved in somitogenesis
           |   |__fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation
           |   |__fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
           |   |__positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
           |   |__positive regulation of posterior neural plate formation by fibroblast growth factor receptor signaling pathway
           |__glial cell-derived neurotrophic factor receptor signaling pathway
           |   |__GDF15-GFRAL signaling pathway
           |   |__glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
           |__growth hormone receptor signaling pathway
           |   |__growth hormone receptor signaling pathway via JAK-STAT
           |__hepatocyte growth factor receptor signaling pathway
           |__insulin receptor signaling pathway 89 rec.
           |__insulin-like growth factor receptor signaling pathway 4 rec.
           |__Kit signaling pathway
           |__neurotrophin TRK receptor signaling pathway 1 rec.
           |__platelet-derived growth factor receptor signaling pathway
           |   |__platelet-derived growth factor receptor-alpha signaling pathway(+)
           |   |__platelet-derived growth factor receptor-beta signaling pathway(+)
           |   |__VEGF-activated platelet-derived growth factor receptor signaling pathway(+)
           |__sevenless signaling pathway 33 rec.
           |__Tie signaling pathway
           |__torso signaling pathway 34 rec.
           |__vascular endothelial growth factor receptor signaling pathway 45 rec.
           |   |__positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
           |   |__vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
           |   |__vascular endothelial growth factor receptor-1 signaling pathway
           |   |__vascular endothelial growth factor receptor-2 signaling pathway
           |   |__vascular endothelial growth factor receptor-3 signaling pathway
           |__vascular endothelial growth factor signaling pathway
               |__positive regulation of cell migration by vascular endothelial growth factor signaling pathway(+)
               |__VEGF-activated neuropilin signaling pathway(+)
               |__VEGF-activated platelet-derived growth factor receptor signaling pathway(+)
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a enzyme-linked receptor protein signaling pathway
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "transmembrane receptor protein serine/threonine kinase signaling pathway" BROAD
    "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-187015 "Activation of TRKA receptors"