FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term epidermal growth factor receptor signaling pathway ID (Ontology) GO:0007173 (Gene Ontology)
Definition The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
Also Known As "EGF receptor signaling pathway" ; "EGF receptor signalling pathway" ; "EGFR signaling pathway" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      25
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 epidermal growth factor receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)       2     25
     involved_in | epidermal growth factor receptor signaling pathway       --      25
Spanning Tree (Parents/Children)
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  cell surface receptor protein tyrosine kinase signaling pathway
   |__ERBB signaling pathway
       |__epidermal growth factor receptor signaling pathway  85 rec.
           |__epidermal growth factor receptor signaling pathway involved in heart process
           |__epidermal growth factor receptor signaling pathway involved in lung development
           |__epidermal growth factor signaling pathway involved in forebrain neuron fate commitment
           |__ERBB2-EGFR signaling pathway
           |__ERBB4-EGFR signaling pathway
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Is a ERBB signaling pathway
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Synonyms
  • "EGF receptor signaling pathway" EXACT
    "EGF receptor signalling pathway" EXACT
    "EGFR signaling pathway" EXACT
    "epidermal growth factor receptor signalling pathway" EXACT
    "ERBB1 signaling pathway" EXACT
    "receptor tyrosine-protein kinase erbB-1 signaling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-177929 "Signaling by EGFR"