FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term epidermal growth factor catabolic process ID (Ontology) GO:0007174 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor.[ PubMed:2985587 ]
Also Known As "EGF breakdown" ; "EGF catabolism" ; "epidermal growth factor breakdown" (for all, see Synonyms field below)
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macromolecule catabolic process
 |__protein catabolic process__________________________________________________
protein metabolic process                                                      |
 |__protein catabolic process__________________________________________________|
regulation of epidermal growth factor receptor signaling pathway               |
 |__negative regulation of epidermal growth factor receptor signaling pathway__|
negative regulation of ERBB signaling pathway                                  |
 |__negative regulation of epidermal growth factor receptor signaling pathway__|
                                                                               epidermal growth factor catabolic process
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Is a protein catabolic process
negative regulation of epidermal growth factor receptor signaling pathway
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Synonyms
  • "EGF breakdown" EXACT
    "EGF catabolism" EXACT
    "EGF receptor ligand processing" RELATED
    "epidermal growth factor breakdown" EXACT
    "epidermal growth factor catabolism" EXACT
    "epidermal growth factor ligand processing" RELATED
    "intracellular EGF processing" RELATED[ PubMed:2985587 ]
    "receptor-mediated EGF processing" RELATED[ PubMed:1683723 ]
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