FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term transforming growth factor beta receptor signaling pathway ID (Ontology) GO:0007179 (Gene Ontology)
Definition The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Also Known As "TGF-beta receptor signaling pathway" ; "TGF-beta receptor signalling pathway" ; "TGFbeta receptor signaling pathway" (for all, see Synonyms field below)
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 Gene Groups
 transforming growth factor beta receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)       1
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cell surface receptor protein serine/threonine kinase signaling pathway
 |__transforming growth factor beta receptor superfamily signaling pathway__
cellular response to growth factor stimulus                                 |
 |__cellular response to transforming growth factor beta stimulus___________|
response to transforming growth factor beta                                 |
 |__cellular response to transforming growth factor beta stimulus___________|
                                                                            transforming growth factor beta receptor signaling pathway  2 rec.
                                                                             |__regulation of transforming growth factor beta receptor signaling pathway 1 rec.
                                                                             |   |__negative regulation of transforming growth factor beta receptor signaling pathway(+)
                                                                             |   |__positive regulation of transforming growth factor beta receptor signaling pathway 1 rec.
                                                                             |__transforming growth factor beta receptor complex assembly
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Is a transforming growth factor beta receptor superfamily signaling pathway
Part of cellular response to transforming growth factor beta stimulus
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Synonyms
  • "TGF-beta receptor signaling pathway" EXACT
    "TGF-beta receptor signalling pathway" EXACT
    "TGFbeta receptor signaling pathway" EXACT
    "TGFbeta receptor signalling pathway" EXACT
    "transforming growth factor beta receptor signalling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-170834 "Signaling by TGF-beta Receptor Complex"