FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term phospholipase C-activating G protein-coupled receptor signaling pathway ID (Ontology) GO:0007200 (Gene Ontology)
Definition A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 regulates the opening of calcium channels in intracellular calcium store, leading to the release of calcium into the cytosol. Calcium and DAG activate protein kinase C (PKC), which in turn activates downstream effectors.[ ISBN:0815316194 ]
Also Known As "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" ; "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" ; "G-protein coupled receptor signaling pathway coupled to IP3 second messenger" (for all, see Synonyms field below)
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      13
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 phospholipase C-activating G protein-coupled receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)      13
     involved_in | phospholipase C-activating G protein-coupled receptor signaling pathway      13
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  signal transduction
   |__G protein-coupled receptor signaling pathway
       |__phospholipase C-activating G protein-coupled receptor signaling pathway  26 rec.
           |__phospholipase C-activating adrenergic receptor signaling pathway
           |__phospholipase C-activating angiotensin-activated signaling pathway
           |   |__phospholipase C-activating angiotensin-activated signaling pathway involved in heart process
           |__phospholipase C-activating dopamine receptor signaling pathway
           |__phospholipase C-activating endothelin receptor signaling pathway
           |__phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
           |__phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
           |__phospholipase C-activating N-formyl peptide-activated signaling pathway
           |__phospholipase C-activating opsin-mediated signaling pathway 6 rec.
           |__phospholipase C-activating serotonin receptor signaling pathway 2 rec.
           |__phospholipase C-activating tachykinin receptor signaling pathway
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Is a G protein-coupled receptor signaling pathway
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Synonyms
  • "activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED
    "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT
    "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT
    "G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT
    "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT
    "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT
    "phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT
    "PLC-activating GPCR signaling pathway" EXACT
    "protein kinase C-activating G protein-coupled receptor signaling pathway" EXACT
Secondary IDs
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