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General Information
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| Term |
canonical NF-kappaB signal transduction |
ID (Ontology) |
GO:0007249 (Gene Ontology) |
| Definition |
An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).[ PubMed:12773372 PubMed:34659217 ] |
| Also Known As |
"canonical NF-kappaB signaling cascade" ; "I-kappaB kinase/NF-kappaB cascade" ; "I-kappaB kinase/NF-kappaB signal transduction" (for all, see Synonyms field below) |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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| Data Class | Field | Records |
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| Genes (FBgn) | GO_BIOLOGICAL_PROCESS | 2 |
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Genes |
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canonical NF-kappaB signal transduction (all annotations which use CV term, excluding "NOT" statements) | 2 | involved_in | canonical NF-kappaB signal transduction | 2 |
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Relationships
