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| Term | I-kappaB phosphorylation | ID (Ontology) | GO:0007252 (Gene Ontology) |
| Definition | The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.[ PubMed:21772278 PubMed:7594468 ] | ||
| Also Known As | "IkappaB phosphorylation" ; "IKB phosphorylation" ; "inhibitor of kappaB phosphorylation" (for all, see Synonyms field below) | ||
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phosphorylation |__protein phosphorylation__________________ protein modification process | |__protein phosphorylation__________________| intracellular signaling cassette | |__canonical NF-kappaB signal transduction__| I-kappaB phosphorylation |__regulation of I-kappaB phosphorylation |__negative regulation of I-kappaB phosphorylation |__positive regulation of I-kappaB phosphorylation |
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| Is a | protein phosphorylation | ||
| Part of | canonical NF-kappaB signal transduction | ||
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