FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term JNK cascade ID (Ontology) GO:0007254 (Gene Ontology)
Definition A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.[ PubMed:11790549 PubMed:20811974 PubMed:23125017 ]
Also Known As "c-Jun N-terminal kinase cascade" ; "MAPK8 cascade"
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      20
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 Genes
 JNK cascade (all annotations which use CV term, excluding "NOT" statements)      20
     involved_in | JNK cascade      20
Spanning Tree (Parents/Children)
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  intracellular signaling cassette
   |__MAPK cascade
       |__JNK cascade  86 rec.
           |__JUN phosphorylation
           |__regulation of JNK cascade 72 rec.
               |__negative regulation of JNK cascade(+) 29 rec.
               |__positive regulation of JNK cascade 37 rec.
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Is a MAPK cascade
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Synonyms
  • "c-Jun N-terminal kinase cascade" EXACT[ PubMed:20811974 ]
    "JNK1 cascade" NARROW
    "JNK2 cascade" NARROW
    "JNK3 cascade" NARROW
    "MAPK10 cascade" NARROW
    "MAPK8 cascade" EXACT
    "MAPK9 cascade" NARROW
    "SAPK cascade" BROAD
    "stress-activated protein kinase cascade" BROAD
Secondary IDs
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Reactome:R-HSA-450321 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"