FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term chemical synaptic transmission ID (Ontology) GO:0007268 (Gene Ontology)
Definition The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      78
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Relevant FlyBase reports
 Genes
 chemical synaptic transmission (all annotations which use CV term, excluding "NOT" statements)      78
     involved_in | chemical synaptic transmission      78
 NOT | involved_in | chemical synaptic transmission       1
Spanning Tree (Parents/Children)
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  trans-synaptic signaling
   |__anterograde trans-synaptic signaling
       |__chemical synaptic transmission  322 rec.
           |__chemical synaptic transmission, postsynaptic 4 rec.
           |   |__excitatory postsynaptic potential(+) 4 rec.
           |   |__inhibitory postsynaptic potential(+)
           |__excitatory chemical synaptic transmission
           |__induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
           |__inhibitory chemical synaptic transmission
           |__modification of synaptic structure, modulating synaptic transmission
           |__modulation of chemical synaptic transmission 161 rec.
           |   |__modulation of excitatory postsynaptic potential(+) 1 rec.
           |   |__negative regulation of synaptic transmission(+) 19 rec.
           |   |__positive regulation of synaptic transmission(+) 25 rec.
           |   |__postsynaptic modulation of chemical synaptic transmission(+)
           |   |__presynaptic modulation of chemical synaptic transmission(+) 5 rec.
           |   |__regulation of modification of synapse structure, modulating synaptic transmission
           |   |__regulation of neuromuscular synaptic transmission(+) 29 rec.
           |   |__regulation of neurotransmitter secretion(+) 34 rec.
           |   |__regulation of protein catabolic process at synapse, modulating synaptic transmission
           |   |__regulation of spontaneous synaptic transmission(+)
           |   |__regulation of synaptic activity 16 rec.
           |   |__regulation of synaptic plasticity(+) 36 rec.
           |   |__regulation of synaptic transmission, cholinergic(+) 22 rec.
           |   |__regulation of synaptic transmission, dopaminergic(+) 3 rec.
           |   |__regulation of synaptic transmission, GABAergic(+) 2 rec.
           |   |__regulation of synaptic transmission, glutamatergic(+) 9 rec.
           |   |__regulation of synaptic transmission, glycinergic(+)
           |   |__regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
           |   |__regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
           |   |__regulation of translation at synapse, modulating synaptic transmission(+) 2 rec.
           |   |__rhythmic synaptic transmission(+) 2 rec.
           |   |__trans-synaptic signaling, modulating synaptic transmission(+)
           |__neuromuscular synaptic transmission 78 rec.
           |   |__regulation of neuromuscular synaptic transmission(+) 29 rec.
           |   |__synaptic transmission involved in micturition
           |__neuron-neuron synaptic transmission 15 rec.
           |__neurotransmitter secretion 98 rec.
           |   |__acetylcholine secretion, neurotransmission(+)
           |   |__aspartate secretion, neurotransmission
           |   |__asynchronous neurotransmitter secretion
           |   |__catecholamine secretion, neurotransmission(+)
           |   |__evoked neurotransmitter secretion 3 rec.
           |   |__gamma-aminobutyric acid secretion, neurotransmission 1 rec.
           |   |__glutamate secretion, neurotransmission(+) 5 rec.
           |   |__glycine secretion, neurotransmission(+)
           |   |__histamine secretion, neurotransmission
           |   |__neurotransmitter secretion involved in regulation of skeletal muscle contraction
           |   |__octopamine secretion, neurotransmission
           |   |__peptide secretion, neurotransmission(+)
           |   |__primary amine secretion, neurotransmission(+)
           |   |__regulation of neurotransmitter secretion(+) 34 rec.
           |   |__serotonin secretion, neurotransmission
           |   |__spontaneous exocytosis of neurotransmitter
           |   |__spontaneous neurotransmitter secretion(+)
           |   |__substance P secretion, neurotransmission(+)
           |   |__synaptic vesicle exocytosis(+) 59 rec.
           |   |__synchronous neurotransmitter secretion
           |__positive regulation of synapse maturation by synaptic transmission
           |__presynaptic process involved in chemical synaptic transmission
           |__protein catabolic process, modulating synaptic transmission
           |__spontaneous synaptic transmission
           |   |__regulation of spontaneous synaptic transmission(+)
           |   |__spontaneous neurotransmitter secretion(+)
           |__synaptic transmission, cholinergic 34 rec.
           |   |__acetylcholine catabolic process in synaptic cleft 1 rec.
           |   |__acetylcholine secretion, neurotransmission(+)
           |   |__regulation of synaptic transmission, cholinergic(+) 22 rec.
           |__synaptic transmission, dopaminergic 6 rec.
           |   |__dopamine secretion, neurotransmission
           |   |__dopamine uptake involved in synaptic transmission(+) 1 rec.
           |   |__regulation of synaptic transmission, dopaminergic(+) 3 rec.
           |__synaptic transmission, GABAergic 7 rec.
           |   |__gamma-aminobutyric acid secretion, neurotransmission 1 rec.
           |   |__regulation of synaptic transmission, GABAergic(+) 2 rec.
           |__synaptic transmission, glutamatergic 31 rec.
           |   |__glutamate secretion, neurotransmission(+) 5 rec.
           |   |__regulation of synaptic transmission, glutamatergic(+) 9 rec.
           |__synaptic transmission, glycinergic 3 rec.
           |   |__glycine secretion, neurotransmission(+)
           |   |__regulation of synaptic transmission, glycinergic(+)
           |__synaptic transmission, noradrenergic
           |__synaptic transmission, serotonergic
           |__translation at presynapse, modulating chemical synaptic transmission
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Is a anterograde trans-synaptic signaling
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Synonyms
  • "neurotransmission" RELATED
    "signal transmission across a synapse" BROAD
    "synaptic transmission" BROAD
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-112316 "Neuronal System"
Reactome:R-HSA-442720 "CREB1 phosphorylation through the activation of Adenylate Cyclase"
Reactome:R-HSA-442729 "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"
Reactome:R-HSA-442742 "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"
Reactome:R-HSA-451307 "Activation of Na-permeable kainate receptors"
Reactome:R-HSA-451308 "Activation of Ca-permeable Kainate Receptor"
Reactome:R-HSA-9619229 "Activation of RAC1 downstream of NMDARs"
Reactome:R-HSA-9619483 "Activation of AMPK downstream of NMDARs"
Reactome:R-HSA-9620244 "Long-term potentiation"
Wikipedia:Neurotransmission